An intriguing post was made on the subreddit chempros; some difficulties with Grease contamination. If I recall correctly, the team here at Yonsung also had such problems; they utilized a MeCN/Heptane work-up, to force the grease into the heptane layer.
However, here's a different (yet related) trick:
I got you on this one! No idea where this crap comes from, always an issue on small scale. But there's an easy fix. Grease is insoluble in acetonitrile! 😎 So just concentrate your product down, add a small amount of acetonitrile and mix. You'll see the grease crash out like little droplets of fat. Then filter through a syringe filter and concentrate down again and then you'll have a grease-free product! You can go ultra-lazy and just add deuterated acetonitrile to the sample and filter, then just NMR. Either way, your greasy problems will be a thing of the past 👍 Lemme know how it works out for you.
Indeed!
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